Bio-Identical Hormones (Rx)

Natural Hormone Replacement

What Does Natural Mean?

Every day in the United States 3,500 women enter menopause. There are currently over 50 million menopausal women in this country. It is estimated that 15 to 30 percent of these women are taking synthetic hormone replacement. Now they have a safer choice in natural hormone replacement therapy.

Natural can be a confusing term, so let’s define Natural. When a hormone is called natural, that means that it is identical to the hormones the human body normally produces. These include estrone, estradiol, estriol, progesterone, testosterone and dehydroepiandosterone (DHEA). Natural hormones are derived from wild yams and are converted by chemists to hormones which are identical (bio-identical) in every way to those made by the human body. Naturally occurring substances are not patentable, so pharmaceutical companies do not want to research drugs they can’t patent, so most women take patented synthetic hormones.

Fortunately the full range of bio-identical hormones are available through compounding pharmacists in any combination or dose required. Depending on your individual needs, a tailor-made prescription can be created for you. If a female hormonal imbalance or health problem is being addressed, your prescription may include any of the hormones found in the human ovary. These include three estrogens (estradiol, estrone, and estriol) as well as progesterone, testosterone, and DHEA.

Bio-Identical Hormones Saliva Flex Kit for sale at The Natural Pharmacy

Blood vs Saliva when it comes to hormones.

As explained by Eric Sauer – Naturopathic Consultant & Licensed Pharmacist (Video)

Synthetic Hormones

Patented hormones like those found in Premarin™, Prempro™, Provera™ and Estratab™ are not bio-identical to human hormones. Their chemical structure has been altered and they do not act like natural hormones. Premarin™ is from a natural source (pregnant mares’ urine) but it contains many hormones found only in horses. This is not natural to the human body.

The goal of natural hormone therapy is to alleviate the symptoms caused by the decrease in hormone production and bring the body back to hormonal balance. Another goal of natural hormone therapy is to imitate the body’s natural processes as much as possible, thereby eliminating most of the unwanted effects and long term risks of the traditional synthetic hormone replacement therapies.

How It Works

Hormone Related Problems

Did you know that the following range of problems can be hormone related?:

Endometrial and Breast Cancers

Heart Disease



Poor Concentration and Memory

Symptoms of Depression

Lack of Energyo

Vaginal Thinning and Dryness

Hot Flashes

Sleep Difficulties

Poor Blood Flow

Thinning of the Skin


How Can I Be Treated?

The key point is that your doctor first has to be able to recognize that vague, stubborn health problems may be hormone related. Your hormone system (called the endocrine system) is intricately involved with the immune and nervous system, and any imbalances affect you at every level of your being. No hormone in the body works in isolation — they all work in harmonic interdependence with the rest of the body. One of the keys to well being is keeping your hormones in balance.

To evaluate you for hormonal imbalances, in addition to taking a detailed history and making a thorough physical exam, we may test your blood, saliva or urine. Most of us are familiar with blood tests as a way of obtaining information about one’s particular health status, but saliva sampling can provide very useful information, especially for female hormones. Research has clearly established that salivary hormone levels correlate well with blood levels of hormones such as estrogen, progesterone, testosterone, DHEA and cortisol. Salivary hormone levels measure the amount of free hormone in the blood — that is, the part that is biologically active. This gives us an idea of how much hormone your tissues are truly being exposed to. This is difficult to tell from blood tests because so much of the hormone is bound to protein in the blood. Salivary testing is also desirable since it can be done in the convenience of the patients home, is less expensive than blood tests, and multiple samples can be easily taken over a period of time to really see what is happening at the hormonal level.

How It Works

Once your particular hormone imbalances are understood, we can then begin to restore you to good health through individualized dietary adjustments, nutritional supplements, and natural hormone replacement prescribed for your specific needs. To obtain the intended benefits without the side effects of synthetic hormones, we use natural hormones. By natural, we actually mean “identical to natural”, or bio-identical hormones. Although these plant-derived hormones are synthesized in a lab and are not extracted from humans, they are natural in the sense that they are biochemically identical to human hormones. Using nature as the template we attempt to provide your body with what it needs, in familiar form, so it can “fill in the gaps” according to it’s own wisdom.

Why Does This Problem Exist?

Currently in conventional medicine, what is most prescribed for women with any gynecological hormone-related problem, whether it’s PMS, infertility, post-partum depression, post-hysterectomy, menstrual irregularities, or menopause, are strong synthetic hormones that only resemble your body’s own. This is where the problems start. Hormones which are not identical to your own — like Premarin, Provera, and Birth Control Pills — don’t fit! They don’t fit into your hormone receptors like the lock and key they are supposed to, but more like a rectangle trying to fit into a square shape. It’s not only that these synthetic hormones don’t fit, but they also can’t go down the normal metabolic pathways of detoxification and excretion as fast as bio-identical hormones. This means they linger and can accumulate in the body, making them stronger acting and with so many potential side effects.

Unfortunately, these unnatural hormones, in the form of Premarin and Provera, are the most commonly used substances in mainstream American medicine for the correction of women’s hormonal imbalances. Premarin is an estrogen which is made from the urine of pregnant mares — yes, as in horses. Only 1/3 of it’s dose is familiar human estrogens, whereas 2/3 are horse estrogens. These horse estrogens attach more strongly to the human estrogen hormone receptor than native hormones and may take 8 to 14 weeks to clear from the body compared to the one day clearance of native human estrogen. When post-menopausal women on Premarin began to develop uterine cancer, a synthetic form of progesterone, a progestin, was created to counterbalance the strong estrogen. Provera is medroxy-progestrone, a synthetic progestin with properties similar to progesterone but with a different molecular structure, which is many times more potent than natural progesterone. Progestins can produce very different, and often undesirable effects in the body compared to the natural progesterone. Beyond Provera’s numerous side effects, it interferes with your body’s own progesterone production.


Natural Women, Natural Menopause, Marcus Laux, ND and Christine Conrad (New York: Harper Collins, 1997)
Screaming to Be Heard, Elizabeth Lee Vliet, MD (New York: M. Evans and Co., 1995)
Dr. Susan Love’s Hormone Book, Susan Love, MD and Karen Lindsey (New York: Random House, 1997)
The Super Hormone Promise, William Regelson, MD and Carol Colman (New York: Simon & Schuster, 1996)
Susan Weed
Christiane Northrup, MD
John Lee, MD